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pharmacokinetics
Pharmacokinetics describes what the body does to a drug — how it is absorbed, distributed, metabolised, and eliminated. It is modelled using the LADME framework and forms the scientific basis for dosage regimens.
griechisch phármakon = Arznei, kineîn = bewegen
ADME, LADME
pharmacokinetics
Four steps are distinguished, summarised in the acronym LADME (or ADME): Liberation (release), Absorption (uptake), Distribution, Metabolism (transformation), and Excretion (elimination).
The counterpart is pharmacodynamics: it describes what the active substance does to the body. A useful mnemonic: kinetics is the journey, dynamics is the effect.
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